Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Anti-diabetic potential of aerial parts of Galium tricornutum (Dandy) Rubiaceae

Shah Tamas Khan, Mushtaq Ahmed, Rahmat Ali Khan , Nadia Mushtaq, Nisar Khan

Department of Biotechnology, University of Science and Technology Bannu 28100, Pakistan;

For correspondence:- Rahmat Khan Email: rahmatul_81@yahoo.com Tel:+92928633425

Received: 8 April 2016 Accepted: 8 June 2017 Published: 31 July 2017

Citation: Khan ST, Ahmed M, Khan RA, Mushtaq N, Khan N. Anti-diabetic potential of aerial parts of Galium tricornutum (Dandy) Rubiaceae. Trop J Pharm Res 2017; 16(7):1573-1578 doi: 10.4314/tjpr.v16i7.15

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the anti-diabetic potential of methanol extract of the aerial parts of Galium tricornutum (Dandy) in diabetic rats.

Methods: The methanol extract of the aerial parts of Galium tricornutum was first subjected to acute toxicity studies. Thereafter, the effect of the extract on oral glucose tolerance was determined. In addition, the effect of the extract on fasting blood glucose, as well as serum lipid profile, urea, creatinine, alanine transaminase (ALT), aspartate transaminase (AST), bilirubin, alkaline phosphatase (ALP) and protein were investigated in alloxan-induced diabetic rats.

Results: No acute toxicity were observed in the rats after administration of the plant extract up to a dose of 2000 mg/kg. The effect of the extract on glucose tolerance test was significant from 30 to 180 min after treatment. In the diabetic rats, the extract showed significant (p < 0.05) anti-hyperglycemic activity at 400 mg/kg. It also led to significant increases in body weight and HDL-cholesterol, and significant reductions in serum LDL, triglycerides and transaminases (p < 0.05).

Conclusion: These results indicate that the aerial parts of G. tricornutum possess significant anti-diabetic potential.

Keywords: Diabetes, Galium tricornutum, Glibenclamide, Glucose tolerance tes, Lipid profile